التفاصيل البيبلوغرافية
| العنوان: |
Beyond the heart - Exploring the therapeutic potential of PDE3 inhibitors. |
| المؤلفون: |
TRAWALLY, Muhammed |
| المصدر: |
Journal of Research in Pharmacy; 2023, Vol. 27 Issue 6, p2218-2241, 24p |
| مصطلحات موضوعية: |
CYCLIC adenylic acid, CYCLIC guanylic acid, CARDIOVASCULAR diseases, PHOSPHODIESTERASES, HEART, CARDIOVASCULAR agents |
| مستخلص: |
Phosphodiesterases (PDEs) consist of an enzyme family of eleven groups responsible for the hydrolytic breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). cAMP and cGMP are important secondary messengers that regulate physiological functions. The widespread expression of PDE3 in tissues and organs makes it an attractive therapeutic target. For decades, PDE3 inhibitors have been acknowledged as significant pharmaceutical agents in the treatment of cardiovascular disorders due to their inotropic and vasodilatory actions. Emerging data, however, suggests that the potential therapeutic application of PDE3 inhibitors has gone beyond their traditional cardiovascular applications. This comprehensive review aims to explore the noncardiovascular developments related to PDE3 inhibitors, exploring their mechanism of action, and clinical trials. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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