التفاصيل البيبلوغرافية
| العنوان: |
Synthesis, antibacterial activity evaluation and molecular docking studies of coumarin modified thiouracil derivatives as SecA inhibitor. |
| المؤلفون: |
Hong Zhang, Penglei Cui, Xinming Hu, Hongya Li |
| المصدر: |
Synthetic Communications; 2023, Vol. 53 Issue 24, p2097-2107, 11p |
| مصطلحات موضوعية: |
MOLECULAR docking, ANTIBACTERIAL agents, COUMARINS, THIOURACIL, COUMARIN derivatives, MOLECULES, LEAD compounds |
| مستخلص: |
A series of thiouracil derivatives containing coumarin were designed and synthesized with SecA inhibitor 1 as the lead. The in vitro antibacterial activities of the newly synthesized compounds were evaluated, and the results revealed that some of the new compounds (such as 14k and 14q) had strong inhibitory effect against the tested bacteria. The inhibitory activities of 14k, 14 l, 14r, 14p and 14q against SecA were tested, and the IC50 of 14K was 17.6 µg/mL which was significantly lower than that of lead compound 1. The molecular docking of the compounds 14k, 14 l, 14r, 14p and 14q with SecA were investigated and these compounds can successfully bind to SecA in the two selected pocket. Compound 14k had strong SecA inhibitory activity and antibacterial activity, which was worthy of further study. [ABSTRACT FROM AUTHOR] |
|
Copyright of Synthetic Communications is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher 
Full Text Finder