التفاصيل البيبلوغرافية
| العنوان: |
Successful treatment with baricitinib of linear morphea following the lines of Blaschko mimicking lichen striatus. |
| المؤلفون: |
Zou, Quan, Wei, Ruoqu, Yao, Zhirong, Li, Huaguo |
| المصدر: |
Journal of Dermatology; Jan2024, Vol. 51 Issue 1, p115-119, 5p |
| مستخلص: |
Linear morphea, also known as linear scleroderma, is a localized form of scleroderma characterized by the presence of lesions that follow a linear distribution pattern. Apart from the typical inflammation and fibrosis of the skin, the linear subtype of morphea often affects underlying structures such as muscles and bones, which can lead to functional limitations. Lichen striatus, a linear inflammatory skin condition, primarily affects children aged 5 to 15 years. Interestingly, both diseases can exhibit lesions that follow the lines of Blaschko. Here we report a case with linear morphea following the lines of Blaschko mimicking lichen striatus in a 4‐year‐old child. This unique case represents the first documented instance of linear morphea exhibiting a precise Blaschko pattern and being successfully treated with baricitinib. The patient received oral baricitinib at a daily dosage of 2 mg for a duration of 1 year, resulting in remarkable improvement. The majority of the lesions softened, and there was no significant disease progression or occurrence of adverse events throughout the treatment period. Recognizing linear morphea at an early stage is of utmost importance in ensuring effective treatment and preventing disfiguring sequelae. Patients suspected of lichen striatus should also be closely followed and linear morphea should be excluded during the follow‐up. The recent breakthrough in the application and the safety of baricitinib in scleroderma is also reviewed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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