دورية أكاديمية
The Ratio of Cysteine-Rich Angiogenic Inducer 61 to MicroRNA-155 Expression as a Preeclampsia Diagnostic Marker and Predictor of Its Severity.
| العنوان: | The Ratio of Cysteine-Rich Angiogenic Inducer 61 to MicroRNA-155 Expression as a Preeclampsia Diagnostic Marker and Predictor of Its Severity. |
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| المؤلفون: | Shoeib, Sarah Mamdouh, Abdeldaim, Doaa Elwy, Mashal, Shaimaa Samir, Ibrahim, Rowida Raafat, Dawood, Lamees Mohamed, Shatat, Doaa, El-Masry, Yasmine Ibrahim, Almeldin, Ahmed, El Sharaby, Radwa Mahamoud |
| المصدر: | Reports of Biochemistry & Molecular Biology; Jul2023, Vol. 12 Issue 2, p332-359, 8p |
| مصطلحات موضوعية: | PREECLAMPSIA, ENZYME-linked immunosorbent assay, PREGNANT women, POLYMERASE chain reaction, OXIDATIVE stress, RESEARCH personnel |
| مستخلص: | Background: Preeclampsia (PE) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. MicroRNA-155 (miR-155) overexpression in the sera of pregnant women has been linked to preeclampsia. Researchers discovered that miR-155 acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer 61 (CYR61), which causes local ischemia as well as oxidative stress. Methods: The level of miR-155 expression in all serum samples was quantified using real-time polymerase chain reaction (RT-PCR), and serum CYR61 was measured using enzyme-linked immunosorbent assays. Together with the Cyr-61/miR-155 ratio, they were evaluated as biomarkers for PE pathogenesis and severity prediction. Results: MiR-155 expression, serum CYR61 levels, and Cyr-61/miR-155 ratios were all significantly higher in PE patients compared to the control group. Serum CYR61 levels and the Cyr-61/miR-155 ratio differed significantly between mild and severe PE patients. Conclusion: MiR-155 expression, serum CYR61 levels, and Cyr-61/miR-155 may serve as biomarkers for PE pathogenesis and severity prediction. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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