دورية أكاديمية
Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism.
| العنوان: | Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism. |
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| المؤلفون: | Gubin, Denis, Danilenko, Konstantin, Stefani, Oliver, Kolomeichuk, Sergey, Markov, Alexander, Petrov, Ivan, Voronin, Kirill, Mezhakova, Marina, Borisenkov, Mikhail, Shigabaeva, Aislu, Yuzhakova, Natalya, Lobkina, Svetlana, Weinert, Dietmar, Cornelissen, Germaine |
| المصدر: | Biology (2079-7737); Jan2024, Vol. 13 Issue 1, p22, 21p |
| مصطلحات موضوعية: | BLUE light, BODY mass index, ACTIGRAPHY, MELATONIN, VERNAL equinox, CIRCADIAN rhythms |
| مستخلص: | Simple Summary: We examined the relationship between the circadian rhythms of activity, wrist temperature (wT), blue light exposure (BLE) and sleep with proxies of metabolic health (body mass index (BMI), leptin and cortisol) in Arctic residents during a single week at the spring equinox. We found that nocturnal BLE within a distinct time window is associated with a higher BMI but not with the actigraphy indices of sleep or motor activity. We determined an evening time window of non-overlapping 95% confidence intervals of BLE between groups with BMI < 25 and BMI > 25 kg/m2 between 9:30 p.m. and 0:30 a.m., with a threshold that is less than 1 lx. The area under the curve delineated by nocturnal BLE above recommended reference values represents the novel nocturnal excess index (NEIbl), which was the best actigraphy-based predictor of BMI. A higher BMI was also associated with lower 24 h wT, an association mostly characterizing those carrying the MTNR1B rs10830963 G-allele. In this allele carriers, a higher BMI was also closely related to NEIbl. A higher wake-after-sleep onset (WASO) correlated with higher leptin. Higher cortisol was associated with another novel index, the Daylight Deficit Index of blue light, DDIbl, and with an earlier onset of BLE. This study explores the relationship between the light features of the Arctic spring equinox and circadian rhythms, sleep and metabolic health. Residents (N = 62) provided week-long actigraphy measures, including light exposure, which were related to body mass index (BMI), leptin and cortisol. Lower wrist temperature (wT) and higher evening blue light exposure (BLE), expressed as a novel index, the nocturnal excess index (NEIbl), were the most sensitive actigraphy measures associated with BMI. A higher BMI was linked to nocturnal BLE within distinct time windows. These associations were present specifically in carriers of the MTNR1B rs10830963 G-allele. A larger wake-after-sleep onset (WASO), smaller 24 h amplitude and earlier phase of the activity rhythm were associated with higher leptin. Higher cortisol was associated with an earlier M10 onset of BLE and with our other novel index, the Daylight Deficit Index of blue light, DDIbl. We also found sex-, age- and population-dependent differences in the parametric and non-parametric indices of BLE, wT and physical activity, while there were no differences in any sleep characteristics. Overall, this study determined sensitive actigraphy markers of light exposure and wT predictive of metabolic health and showed that these markers are linked to melatonin receptor polymorphism. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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