التفاصيل البيبلوغرافية
| العنوان: |
Clinical profile, referral trends, and real‐world application of vibration‐controlled transient elastography in children with non‐alcoholic fatty liver disease in Singapore. |
| المؤلفون: |
Chiou, Fang Kuan, Goh, Lynette, Ho, Christopher Wen Wei, Rajan, Charanya, Logarajah, Veena, Ng, Lay Queen, Phua, Kong Boo |
| المصدر: |
JGH Open; Jan2024, Vol. 8 Issue 1, p1-7, 7p |
| مصطلحات موضوعية: |
FATTY liver, NON-alcoholic fatty liver disease, ALANINE aminotransferase, ASPARTATE aminotransferase, ELASTOGRAPHY |
| مصطلحات جغرافية: |
SINGAPORE |
| مستخلص: |
Background and Aim: Pediatric non‐alcoholic fatty liver disease (NAFLD) is a progressive disorder that is increasing in incidence globally. The study aims to describe the clinical profile and longitudinal outcome, including the utility of vibration‐controlled transient elastography (VCTE), in children with NAFLD at a single tertiary liver unit in Singapore. Methods: Retrospective review of patients aged 0–18 years referred for NAFLD from 2003 to 2020 was conducted. Diagnosis was based on persistent elevation of alanine transaminase ≥2× the upper limit of normal in at‐risk patients, and/or radiologic detection of hepatic steatosis, with the exclusion of other etiologies. VCTE‐derived liver stiffness measurements (LSMs) ≤7.0 , 7.1–9.0, and ≥9.1 kPa were used to differentiate normal (F0–F1), significant fibrosis (F2), and advanced fibrosis (F3–F4), respectively. Results: The study included 210 patients (72.4% male, mean age 11.6 years). New cases increased from 1.7/1000 referrals in 2003–2008 to 12.7 and 24.5/1000 referrals in 2009–2014 and 2015–2020, respectively. Significant proportion had dyslipidemia (41.4%), impaired glucose tolerance/diabetes (IGT/DM, 26.7%), and hypertension (17.1%). Only 6.2% had resolution of NAFLD after a mean follow‐up of 3.7 years. Based on VCTE (n = 65), 41.5% had normal LSM, while 26.2% and 32.3% had increased likelihood of significant and advanced fibrosis, respectively. Age ≥16 years (odds ratio [OR] 8.9), IGT/DM (OR 6.5), and aspartate transaminase >70 U/L (OR 11.0) were independent risk factors associated with increased likelihood of advanced fibrosis. Conclusion: Incidence of pediatric NAFLD has increased dramatically in Singapore. Based on LSM estimation, pediatric NAFLD may be associated with an increased risk of developing advanced fibrosis by late adolescence. [ABSTRACT FROM AUTHOR] |
|
Copyright of JGH Open is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder