التفاصيل البيبلوغرافية
| العنوان: |
Cryptococcal meningoencephalitis in multiple sclerosis treated with fingolimod. |
| المؤلفون: |
Nasir, Moneeb, Galea, Ian, Neligan, Aidan, Chung, Karen |
| المصدر: |
Practical Neurology; Dec2023, Vol. 23 Issue 6, p512-515, 5p |
| مصطلحات موضوعية: |
MENINGITIS diagnosis, MULTIPLE sclerosis, C-reactive protein, OPPORTUNISTIC infections, AMPHOTERICIN B, NAUSEA, INTRAVENOUS therapy, HETEROCYCLIC compounds, ORAL drug administration, IMMUNOLOGIC receptors, MAGNETIC resonance imaging, DIFFERENTIAL diagnosis, LYMPHOPENIA, SUBARACHNOID hemorrhage, CRYPTOCOCCUS neoformans, LUMBAR puncture, IMMUNOSUPPRESSIVE agents, FLUCONAZOLE, MENINGITIS, HEADACHE, CEREBROSPINAL fluid, MENINGOENCEPHALITIS, SPHINGOSINE-1-phosphate, CHEMICAL inhibitors, DISEASE risk factors |
| مستخلص: |
A 21-year-old woman with multiple sclerosis (taking regular fingolimod) developed sudden-onset severe headache with nausea and malaise. Neurological examination was normal and she was afebrile. Blood results showed lymphocytes 0.53 x 109/L and C reactive protein 19 mg/L. CT scan of head and venogram were normal. CSF showed an opening pressure of 33 cm H2O and an incidental light growth of Cryptococcus neoformans, confirmed with positive India Ink stain and a positive cryptococcal antigen (1:100). She was treated for cryptococcal meningoencephalitis with amphotericin and flucytosine. Her presenting symptoms had closely mimicked subarachnoid haemorrhage. This atypical presentation of cryptococcal CNS infection highlights the need for vigilance in immunosuppressed patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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