دورية أكاديمية
Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals.
| العنوان: | Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals. |
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| المؤلفون: | Stojković, Maja, Todorović, Zoran, Protic, Dragana, Stevanovic, Strahinja, Medić, Dragana, Charvet, Claude L., Marjanović, Djordje S., Trailović, Jelena Nedeljković, Trailović, Saša M. |
| المصدر: | Frontiers in Pharmacology; 2024, p1-11, 11p |
| مصطلحات موضوعية: | NEUROMUSCULAR system, NEMATODE infections, ASCARIS suum, CAENORHABDITIS elegans, SPASTIC paralysis, RATS, NEMATODES, CAENORHABDITIS |
| مستخلص: | The control of parasitic nematode infections relies mostly on anthelmintics. The potential pharmacotherapeutic application of phytochemicals, in order to overcome parasite resistance and enhance the effect of existing drugs, is becoming increasingly important. The antinematodal effects of carveol was tested on the free-living nematode Caenorhabditis elegans and the neuromuscular preparation of the parasitic nematode Ascaris suum. Carveol caused spastic paralysis in C. elegans. InA. suum carveol potentiated contractions induced by acetylcholine (ACh) and this effect was confirmed with two-electrode voltage-clamp electrophysiology on the A. suum nicotinic ACh receptor expressed in Xenopus oocytes. However, potentiating effect of carveol on ACh-induced contractions was partially sensitive to atropine, indicates a dominant nicotine effect but also the involvement of some muscarinic structures. The effects of carveol on the neuromuscular system of mammals are also specific. In micromolar concentrations, carveol acts as a noncompetitive ACh antagonist on ileum contractions. Unlike atropine, it does not change the EC |
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| قاعدة البيانات: | Complementary Index |
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