دورية أكاديمية
Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence.
| العنوان: | Function of proprotein convertase subtilisin/kexin type 9 and its role in central nervous system diseases: An update on clinical evidence. |
|---|---|
| المؤلفون: | Zhu, Xiao‐Bin, Xu, Yao‐Yao, Li, Liu‐Cheng, Sun, Jia‐Bin, Wang, Yu‐Zhen, Chen, Jie, Wang, Chen, Zhang, Su, Jin, Liang‐Yan |
| المصدر: | Drug Development Research; Feb2024, Vol. 85 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: | CENTRAL nervous system diseases, SUBTILISINS, LDL cholesterol, ALZHEIMER'S disease, CHOLESTEROL metabolism |
| مستخلص: | Proprotein convertase subtilisin/kexin type 9 (PCSK9) has attracted lots of attention in preventing the clearance of plasma low‐density lipoprotein cholesterol (LDL‐C). PCSK9 inhibitors are developed to primarily reduce the cardiovascular risk by lowering LDL‐C level. Recently, a number of pleiotropic extrahepatic functions of PCSK9 beyond the regulation of cholesterol metabolism, particularly its effects on central nervous system (CNS) diseases have been increasingly identified. Emerging clinical evidence have revealed that PCSK9 may play a significant role in neurocognition, depression, Alzheimer's disease, and stroke. The focus of this review is to elucidate the functions of PCSK9 and highlight the effects of PCSK9 in CNS diseases, with the aim of identifying the potential risks that may arise from low PCSK9 level (variant or inhibitor) in the clinical practice. [ABSTRACT FROM AUTHOR] |
| Copyright of Drug Development Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder كن أول من يترك تعليقا!