دورية أكاديمية
Immunosensing Cancer Markers through Surface-Enhanced Photoluminescence on Nanostructured Silver Substrates †.
| العنوان: | Immunosensing Cancer Markers through Surface-Enhanced Photoluminescence on Nanostructured Silver Substrates †. |
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| المؤلفون: | Geka, Georgia, Kanioura, Anastasia, Kochylas, Ioannis, Likodimos, Vlassis, Gardelis, Spiros, Chatzantonaki, Kalliopi, Charvalos, Ekaterina, Dimitriou, Anastasios, Papanikolaou, Nikolaos, Economou, Anastasios, Kakabakos, Sotirios, Petrou, Panagiota |
| المصدر: | Engineering Proceedings; 2023, Vol. 35 Issue 1, p7, 7p |
| مصطلحات موضوعية: | SILVER nanoparticles, PHOTOLUMINESCENCE, EPIDIDYMIS, IMMUNOASSAY, OVARIAN cancer diagnosis, BIOSENSORS |
| مستخلص: | Noble metal nanostructured substrates enhance photoluminescence emitted from molecules immobilized onto their surface, allowing for the development of highly sensitive immunoassays employing fluorescent labels. In this work, nanostructured silver surfaces were implemented as substrates for the immunochemical detection of two ovarian cancer markers, carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4). Biotinylated detection antibodies were used to allow for the detection of immunocomplexes through a reaction with streptavidin conjugated to Rhodamine Red-X. The detection limits achieved were 2.5 U/mL and 0.06 ng/mL for CA125 and HE4, respectively, with linear dynamic ranges, covering the concentration ranges of both healthy and ovarian cancer patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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