دورية أكاديمية

HIIT Induces Stronger Shifts within the Peripheral T Cell Compartment Independent of Sex.

التفاصيل البيبلوغرافية
العنوان: HIIT Induces Stronger Shifts within the Peripheral T Cell Compartment Independent of Sex.
المؤلفون: Proschinger, Sebastian, Schenk, Alexander, Metcalfe, Alan J., Zimmer, Philipp
المصدر: International Journal of Sports Medicine; Mar2024, Vol. 45 Issue 3, p211-221, 11p
مصطلحات موضوعية: EXERCISE & psychology, FLOW cytometry, RUNNING, ATHLETES, SEX distribution, RANDOMIZED controlled trials, COMPARATIVE studies, EXERCISE intensity, RESEARCH funding, HIGH-intensity interval training, T cells, CROSSOVER trials, STATISTICAL sampling
مستخلص: Acute exercise induces changes within the T-cell compartment, especially in cytotoxic CD8+ memory subsets, depending on exercise intensity and duration. It is unclear whether exercise-induced changes in major T-cell subsets differ in response to acute high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific effects exist. Twenty-four recreationally active runners (females: n=12, 27.8±4.1years, 54.4±4.6 ml*kg-1 *min-1 ; males: n=12, 31.6±3.8years, 58.9±7.7 ml*kg-1 *min-1) participated in this randomized controlled crossover study, and conducted an energy- and duration-matched HIIT and MICT session. Blood was sampled before (T1), immediately (T2) and 1 h after exercise (T3). Flow cytometry was used to identify T-cell populations. HIIT decreased the proportion of CD8+ T-cells more pronounced at T3 compared to MICT (p=0.007), induced a significantly stronger increase in the CD8+ effector memory (TEM) cell proportion at T2 (p=0.032), and decreased CD4+ central memory proportion more pronounced at T2 (p=0.029). A decrease below baseline CD8+ TEM proportion at T3 was observed only after HIIT (p<0.001). No interaction effects between sexes were revealed. Taken together, HIIT represents a more potent stimulus to induce shifts mainly within the cytotoxic CD8+ T-cell compartment, thereby giving implications to investigate the role of HIIT on the cell´s effector phenotype and function in more detail. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Sports Medicine is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
قاعدة البيانات: Complementary Index