دورية أكاديمية
Ischemiamodified albumin: a novel blood marker of endoscopic mucosal healing in inflammatory bowel disease.
| العنوان: | Ischemiamodified albumin: a novel blood marker of endoscopic mucosal healing in inflammatory bowel disease. |
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| المؤلفون: | Seung Bum Lee, HyunKi Kim, Sang Hyuk Park, JiHun Lim, Sang Hyoung Park |
| المصدر: | Intestinal Research; Jan2024, Vol. 22 Issue 1, p75-81, 7p |
| مصطلحات موضوعية: | INFLAMMATORY bowel disease diagnosis, ULCERATIVE colitis, ENDOSCOPY |
| مستخلص: | Background/Aims: The achievement of endoscopic remission is an important therapeutic goal in the treatment of inflammatory bowel diseases (IBD). We aimed to evaluate the role of fecal calprotectin (FCP) and ischemiamodified albumin (IMA) as biomarkers for evaluating IBD disease activity. Methods: A total of 48 patients with IBD (20 with ulcerative colitis and 28 with Crohn's disease) were included in this study. FCP and serum Creactive protein levels, erythrocyte sedimentation rate, and IMA were measured in patients with IBD and compared with endoscopic findings. Results: Elevated FCP and serum IMA levels were significantly associated with endoscopic nonmucosal healing. The correlation between FCP and IMA was not significant. Analysis of the receiver operating characteristic curve showed that both FCP and IMA had diagnostic value in predicting nonmucosal healing. When the Ln(FCP)+IMA/10 value was calculated using both factors, the predictive value for nonmucosal healing increased; however, no significant difference was observed. Conclusions: IMA could be a candidate serum biomarker for predicting endoscopic mucosal healing in IBD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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