دورية أكاديمية
Markhamia lutea leaves aqueous and ethanolic extract with curative anti-inflammatory activity attenuates paclitaxel toxicity in rat's intestine.
العنوان: | Markhamia lutea leaves aqueous and ethanolic extract with curative anti-inflammatory activity attenuates paclitaxel toxicity in rat's intestine. |
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المؤلفون: | Ngoufack Azanze, Elvira, Mbiantcha, Marius, Madjo, Kouam Yacine Karelle, Yousseu, Nana Willaim, Fagni Njoya, Zenab Linda, Adjouzem, Carine Flore, Matah Marthe, Vanessa Mba, Ateufack, Gilbert |
المصدر: | Journal of Complementary & Integrative Medicine; Mar2024, Vol. 21 Issue 1, p1-13, 13p |
مصطلحات موضوعية: | ANTI-inflammatory agents, DRUG toxicity, NONSTEROIDAL anti-inflammatory agents, WEIGHT loss, CELL proliferation, INTESTINAL diseases, IN vivo studies, CYCLOOXYGENASE 2, ALKALINE phosphatase, PLANT extracts, RATS, REACTIVE oxygen species, ANIMAL experimentation, ALANINE aminotransferase, PACLITAXEL, CYTOKINES, TUMOR necrosis factors, INTERLEUKINS, PHARMACODYNAMICS |
مستخلص: | Markhamia lutea (M. lutea, Bignoniaceae) is mainly found in tropical/neotropical regions of America, Africa and Asia. The plant's leaves, stems or roots are used to treat anaemia, bloody diarrhoea, parasitic and microbial infections. This study evaluates anti-inflammatory properties (in vitro) of Markhamia lutea and their curative effects on paclitaxel-induced intestinal toxicity (in vivo). The anti-inflammatory potential of Markhamia lutea was tested over cytokines (TNF-alpha, IL-6, IL-1β, IL-10), reactive oxygen species (ROS) and enzymes (cyclooxygenase and 5-lipoxygenase). While in vivo, intestinal toxicity was induced for 10 days by oral administration of paclitaxel (3 mg/kg, 0.05 mL). Animals in each group were further treated with aqueous (300 mg/kg) and ethanolic (300 mg/kg) leaves extracts of Markhamia lutea during 7 days and clinical symptoms were recorded, hematological, biochemical and histological analysis were subsequently performed. In vitro, aqueous (250 μg/mL) and ethanolic (250 μg/mL) extracts of Markhamia lutea inhibited the activities of cyclooxygenase 1 (56.67 % and 69.38 %), cyclooxygenase 2 (50.67 % and 62.81 %) and 5-lipoxygenase (77.33 % and 86.00 %). These extracts inhibited the production of intracellular ROS, extracellular ROS and cell proliferation with maximum IC |
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قاعدة البيانات: | Complementary Index |
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