التفاصيل البيبلوغرافية
| العنوان: |
OCTN2- and ATB0,+-targeted nanoemulsions for improving ocular drug delivery. |
| المؤلفون: |
Tang, Bo, Wang, Qiuxiang, Zhang, Guowei, Zhang, Aiwen, Zhu, Lu, Zhao, Rongrong, Gu, Hongwei, Meng, Jie, Zhang, Junfang, Fang, Guihua |
| المصدر: |
Journal of Nanobiotechnology; 3/26/2024, Vol. 22 Issue 1, p1-19, 19p |
| مصطلحات موضوعية: |
OCULAR pharmacology, DRUG instillation, DRUG bioavailability, DRUG delivery systems, EYE drops |
| مستخلص: |
Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L-carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms of size, morphology, zeta potential, encapsulation efficiency, and in vitro drug release behavior were characterized. The cellular uptake and mechanisms of SC-NEs were comprehensively studied in human corneal epithelial cells and the stearoyl L-carnitine ratio in SC-NEs was optimized. The optimized SC-NEs could target the novel organic cation/carnitine transporter 2 (OCTN2) and amino acid transporter B (0 +) (ATB0,+) on the corneal epithelium, which led to superior corneal permeation, ocular surface retention ability, ocular bioavailability. Furthermore, SC-NEs showed excellent in vivo anti-inflammatory efficacy in a rabbit model of endotoxin-induced uveitis. The ocular safety test indicated that the SC-NEs were biocompatible. In general, the current study demonstrated that OCTN2 and ATB0,+-targeted nanoemulsions were promising ophthalmologic drug delivery systems that can improve ocular drug bioavailability and boost the therapeutic effects of drugs for eye diseases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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