دورية أكاديمية
The Role of Abdominal Surgery in Refractory Immune Checkpoint Inhibitor Enterocolitis: A Case Report.
| العنوان: | The Role of Abdominal Surgery in Refractory Immune Checkpoint Inhibitor Enterocolitis: A Case Report. |
|---|---|
| المؤلفون: | Verhé, Manon, De Somer, Thomas, Defoort, Barbara, Vanderstraeten, Erik, Monsaert, Els, Bouderez, Vincent, Dias, Stefanie, Delombaerde, Danielle, Vulsteke, Christof, Van Steenkiste, Christophe |
| المصدر: | Case Reports in Oncology; 2023, Vol. 16 Issue 1, p453-460, 8p |
| مصطلحات موضوعية: | IMMUNE checkpoint inhibitors, ABDOMINAL surgery, ENTEROCOLITIS, IMMUNOTHERAPY, IMMUNOSUPPRESSIVE agents, BOWEL obstructions |
| مستخلص: | This article describes the case of a 73-year-old patient with grade 3 immune checkpoint inhibitor (ICI)-induced enteritis. Five different immunosuppressive agents (glucocorticoids, high-dose infliximab, methotrexate, mycophenolate mofetil, and vedolizumab) were administered, however, with no clinical or radiographical benefit. A laparotomy was performed, as the patient showed signs of intestinal obstruction, with a segmental resection of the ileal loop. Biopsy results showed multiple fibrotic strictures. The current treatment guidelines for ICI enterocolitis only include drugs as a treatment option. Nevertheless, it remains important to consider early surgical intervention in order to avoid serious complications due to persistent and pronounced inflammation. The current case highlights the importance of surgery as a treatment modality in the multidisciplinary approach for ICI-induced enteritis, which should be taken into consideration after second- or third-line treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Case Reports in Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder كن أول من يترك تعليقا!