دورية أكاديمية
Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery.
| العنوان: | Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery. |
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| المؤلفون: | Natsui, Hiroyuki, Watanabe, Masaya, Yokota, Takashi, Tsuneta, Satonori, Fumoto, Yoshizuki, Handa, Haruka, Shouji, Matsushima, Koya, Jiro, Nishino, Kotaro, Tatsuta, Daishiro, Koizumi, Takuya, Kadosaka, Takahide, Nakao, Motoki, Koya, Taro, Temma, Taro, Ito, Yoichi M., Kanako, Hatanaka C., Hatanaka, Yutaka, Yasushige, Shingu, Wakasa, Satoru |
| المصدر: | Physiological Reports; Mar2024, Vol. 12 Issue 6, p1-15, 15p |
| مصطلحات موضوعية: | EPICARDIAL adipose tissue, ATRIAL fibrillation, FAT cells, TUMOR necrosis factors, LOGISTIC regression analysis |
| مستخلص: | Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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