التفاصيل البيبلوغرافية
| العنوان: |
T-cell count and T-cell telomere length in patients with severe COVID-19. |
| المؤلفون: |
Kraft, Bryan D., Verhulst, Simon, Tsung-Po Lai, Sullenger, Bruce A., Yunfei Wang, Rountree, Wes, Lingye Chen, Woods, Christopher W., Denny, Thomas N., Aviv, Abraham |
| المصدر: |
Frontiers in Immunology; 2024, p1-5, 5p |
| مصطلحات موضوعية: |
COVID-19, T cells, LYMPHOPENIA, TELOMERES, MULTIPLE regression analysis, INTENSIVE care units |
| مستخلص: |
Lymphocyte telomere length (TL) is highly variable and shortens with age. Short telomeres may impede TL-dependent T-cell clonal expansion with viral infection. As SARS-CoV-2 infection can induce prolonged and severe T-cell lymphopenia, infected adults, and particularly older adults with short telomeres, may display severe T-cell lymphopenia. To examine the relationship between Tcell TL parameters and T-cell counts, we studied 40 patients hospitalized with severe COVID-19. T-cells were isolated from lymphocytes, counted using flow cytometry, and their TL parameters were measured using the Telomere Shortest Length Assay. The cohort (median age = 62 years, 27% female) was racially and ethnically diverse (33% White, 35% Black, and 33% Other). On intensive care unit study day 1, T-cell count (mean=1.03 x109/L) was inversely related to age (p=0.007) and higher in females than males (p=0.025). Mean TL was 3.88 kilobases (kb), and 45.3% of telomeres were shorter than 3 kb. Using multiple regression analysis and adjusting for age and sex, T-cell count decreased with increased proportion of T-cell telomeres shorter than 3 kb (p=0.033) and increased with mean TL (p=0.052). Our findings suggest an association between the buildup of short telomeres within T-cells and explain in part reduced peripheral blood T-cell counts in patients with severe COVID-19. Shortened T-cell telomeres may be a risk factor for COVID-19-associated Tcell lymphopenia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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