التفاصيل البيبلوغرافية
| العنوان: |
Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054. |
| المؤلفون: |
Wang, Qinghua, Zhao, Jing, Liu, Zhaoyuan, Ding, Shaoxiong, Huang, Zhiyong, Chen, Jun |
| المصدر: |
International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 6, p3127, 14p |
| مصطلحات موضوعية: |
MARINE biology, STREPTOMYCES, NATURAL products, MARINE bacteria, GENE clusters, SYNTHETIC biology |
| مستخلص: |
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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