دورية أكاديمية
Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway.
العنوان: | Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway. |
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المؤلفون: | Dong, Mingran, Lu, Juan, Xue, Hongwei, Lou, Yang, Li, Shuyang, Liu, Tao, Ding, Zimian, Chen, Xi |
المصدر: | Pharmaceuticals (14248247); Mar2024, Vol. 17 Issue 3, p322, 23p |
مصطلحات موضوعية: | INHIBIN, ANTHOCYANINS, POLLUTANTS, SPERMATOGENESIS, OXIDATIVE stress, MALE reproductive organs, SIRTUINS, CELLULAR signal transduction |
مستخلص: | Cadmium (Cd) is a hazardous heavy metal environmental pollutant that has carcinogenic, teratogenic, and mutagenic properties. Excessive exposure to Cd can induce oxidative stress, which greatly harms the male reproductive system. Anthocyanins have remarkable antioxidative, anti-inflammatory, and anti-stress properties. In this study, we investigated the effects of anthocyanins and the underlying mechanisms through which anthocyanins mitigate Cd-induced reproductive damage. We isolated and purified Lycium ruthenicum Murray anthocyanin extract (LAE) and performed UHPLC-MS/MS to identify 30 different anthocyanins. We established an ICR mouse Cd injury model by administering 5 mg/kg/day CdCl |
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قاعدة البيانات: | Complementary Index |
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