التفاصيل البيبلوغرافية
العنوان: |
A Case of Aggressive Lung Squamous Cell Carcinoma With Aberrant Cytoplasmic p53 Aggregation. |
المؤلفون: |
HIROYUKI YAMADA, RIN YAMADA, YOSHIHIRO KOMOHARA, REMI MITO, KAZUCHIKA NISHITSUJI, HIROMU YANO, YUKIO FUJIWARA, KOEI IKEDA, MAKOTO SUZUKI |
المصدر: |
Cancer Diagnosis & Prognosis; Mar/Apr2024, Vol. 4 Issue 2, p204-208, 5p |
مصطلحات موضوعية: |
SQUAMOUS cell carcinoma, JAPANESE people, LUNG cancer, BIOMARKERS, CANCER cells |
مستخلص: |
Background: Immunohistochemistry for p53 was a well-established method for cancer diagnosis in pathology. Aberrant cytoplasmic p53 positivity reflects the accumulation of p53 aggregates, which has been shown to be associated with chemoresistance and to be a predictive marker of a worse clinical course in ovarian cancer. Case Report: A 65-year-old Japanese man was diagnosed with lung cancer, and surgical resection was performed. Multiple metastasis were found 21 months post-surgery. The lesions were resistant to chemotherapy, and he succumbed to the disease 29 months post-surgery. The resected primary lesion was pathologically diagnosed as squamous cell carcinoma, with notable cytoplasmic p53 positivity indicated by immunohistochemistry. Conclusion: Notable aberrant cytoplasmic accumulation of p53 aggregate was observed in the cancer cells of this case. Chemotherapy was ineffective for the recurrent lesions, suggesting a role of p53 aggregates in chemoresistance. Pathological analysis of p53 via immunohistochemistry may be useful in predicting chemoresistance of lung squamous cell carcinoma. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Diagnosis & Prognosis is the property of International Institute of Anticancer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |