التفاصيل البيبلوغرافية
| العنوان: |
A Case of Aggressive Lung Squamous Cell Carcinoma With Aberrant Cytoplasmic p53 Aggregation. |
| المؤلفون: |
HIROYUKI YAMADA, RIN YAMADA, YOSHIHIRO KOMOHARA, REMI MITO, KAZUCHIKA NISHITSUJI, HIROMU YANO, YUKIO FUJIWARA, KOEI IKEDA, MAKOTO SUZUKI |
| المصدر: |
Cancer Diagnosis & Prognosis; Mar/Apr2024, Vol. 4 Issue 2, p204-208, 5p |
| مصطلحات موضوعية: |
SQUAMOUS cell carcinoma, JAPANESE people, LUNG cancer, BIOMARKERS, CANCER cells |
| مستخلص: |
Background: Immunohistochemistry for p53 was a well-established method for cancer diagnosis in pathology. Aberrant cytoplasmic p53 positivity reflects the accumulation of p53 aggregates, which has been shown to be associated with chemoresistance and to be a predictive marker of a worse clinical course in ovarian cancer. Case Report: A 65-year-old Japanese man was diagnosed with lung cancer, and surgical resection was performed. Multiple metastasis were found 21 months post-surgery. The lesions were resistant to chemotherapy, and he succumbed to the disease 29 months post-surgery. The resected primary lesion was pathologically diagnosed as squamous cell carcinoma, with notable cytoplasmic p53 positivity indicated by immunohistochemistry. Conclusion: Notable aberrant cytoplasmic accumulation of p53 aggregate was observed in the cancer cells of this case. Chemotherapy was ineffective for the recurrent lesions, suggesting a role of p53 aggregates in chemoresistance. Pathological analysis of p53 via immunohistochemistry may be useful in predicting chemoresistance of lung squamous cell carcinoma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
