التفاصيل البيبلوغرافية
| العنوان: |
Clinical Features of Non-Hodgkin Lymphoma-Associated Hemophagocytic Syndrome: a Retrospective Study. |
| المؤلفون: |
Chunxiu Wu, Huiyong Liu, Jianlan Chen |
| المصدر: |
Clinical Laboratory; 2024, Vol. 70 Issue 4, p701-708, 8p |
| مصطلحات موضوعية: |
HEMOPHAGOCYTIC lymphohistiocytosis, RITUXIMAB, HEMORHEOLOGY, PROPORTIONAL hazards models, B cell lymphoma, KILLER cells, SERUM albumin |
| مستخلص: |
Background: This study aims to improve the understanding of lymphoma-associated hemophagocytic syndrome, and find effective methods to identify and manage this fatal disease. Methods: Patients diagnosed with non-Hodgkin lymphoma-associated hemophagocytic syndrome from January 2008 to December 2022 in our center were included. Univariate and multivariate analyses were also conducted using the Cox proportional hazards model. Results: Among 26 patients, 22 patients were diagnosed with T/NK cell lymphoma, while 4 patients were diagnosed with diffuse large B cell lymphoma. A total of 16 patients died with a median follow-up of 71 (26, 236) days. Compared with B cell lymphoma-associated hemophagocytic syndrome patients, T/NK cell lymphoma patients are younger, have lower platelet count, fibrinogen concentration, and serum albumin, have higher blood ß2-microglobulin levels and ferritin, are more likely to be infected with Epstein-Barr virus, are more inclined have a simultaneously occurrence of lymphoma and hemophagocytic syndrome. In multivariate analysis, fibrinogen, albumin, cholinesterase, uric acid, triglyceride, and ferritin are significantly associated with overall mortality. Conclusions: LAHS is a rare disease with poor prognosis. Early anti-inflammatory treatment combined with antilymphoma therapy can improve the overall survival time of patients. Prospective multi-center studies with larger sample sizes and longer follow-up periods are needed to further investigate optimal treatment and prognosis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
