التفاصيل البيبلوغرافية
| العنوان: |
Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress. |
| المؤلفون: |
Wang, Yin-Yuan, Ni, Jian-Cheng, Zhao, Yue-Qin, Yang, Xu, Niu, Zhen-Peng, Yang, Xing-Zhi, Dong, Xian-Xiang, Zhao, Yu-Han, Hao, Xiao-Jiang, Ding, Xiao |
| المصدر: |
Journal of Asian Natural Products Research; May2024, Vol. 26 Issue 5, p562-574, 13p |
| مصطلحات موضوعية: |
LYSOSOMES, AUTOPHAGY, HOMEOSTASIS, PHOSPHORYLATION, RESEARCH funding, TERPENES, BIOLOGICAL transport, POLYMERASE chain reaction, OXIDATIVE stress, TRANSCRIPTION factors, PLANT roots, CULTURE media (Biology), DESCRIPTIVE statistics, GENE expression, CELL lines, REACTIVE oxygen species, MEDICINAL plants, METABOLISM, ANTIOXIDANTS, ONE-way analysis of variance, WESTERN immunoblotting, DRUG development, MICROSCOPY, STAINS & staining (Microscopy), GENETIC techniques, DATA analysis software, CULTURES (Biology) |
| مستخلص: |
Morinda officinalis is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from M. officinalis were evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed light on the identification of autophagy activators from M. officinalis and provide a basis for developing them in the treatment of oxidative stress-involved diseases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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