التفاصيل البيبلوغرافية
| العنوان: |
全身免疫炎症指数联合血清 CXCL5、CXCL12 预测高级别脑胶质瘤患者 术后复发的临床研究. (Chinese) |
| Alternate Title: |
Clinical Study of Systemic Immune Inflammatory Index Combined with Serum CXCL5 and CXCL12 in Predicting Recurrence in Patients with High Grade Glioma after Operation. (English) |
| المؤلفون: |
张瑞剑, 韩志桐, 王 忠, 赵卫平, 孙 鹏, 张彦娜, 王诗秋, 刘玮珉, 金 毅, 常 虹 |
| المصدر: |
Progress in Modern Biomedicine; 2024, Vol. 24 Issue 7, p1396-1400, 5p |
| Abstract (English): |
Objective: To investigate the value of systemic immune inflammatory index (SII) combine with serum CXC chemokine ligand 5 (CXCL5) and chemokine ligand 12 (CXCL12) in predicting recurrence in patients with high grade glioma (HGG) after operation. Methods: 169 patients with HGG who were underwent operation treatment in our hospital from January 2019 to January 2022 were selected. Neutrophil, lymphocyte, platelet count and serum CXCL5, CXCL12 levels were detected in patients with HGG, and SII was calculated before operation. Patients were followed up 1 year, patients with HGG were divided into recurrence group (113 cases) and non recurrence group (56 cases) according to the recurrence after operation. The influencing factors of recurrence in patients with HGG after operation were analyzed by multivariate Logistic regression analysis. The value of SII combine with serum CXCL5 and CXCL12 in predicting recurrence in patients with HGG after operation were analyzed by receiver operating characteristic (ROC) curve. Results: The levels of SII and serum CXCL5 and CXCL12 in recurrent group were higher than those in non recurrent group (P<0.05). The recurrence of patients with HGG after operation was related to age, KPS score before operation, WHO pathological grade, surgical resection range and after operation treatment (P<0.05), and not to gender (P>0.05). Multivariate logistic analysis showed that, WHO pathological grade IV, surgical resection range were incomplete resection, elevated SII, elevated serum CXCL5, and elevated CXCL12 were risk factors for recurrence in patients with HGG after operation (P<0.05). The area under the curve of SII, serum CXCL5 and CXCL12 alone in predicting recurrence of patients with HGG after operation was 0.820, 0.875 and 0.845, respectively, the area under the curve of combined detection was 0.964, which was higher than that of single index detection. Conclusion: Elevate SII, elevate serumCXCL5, and elevate CXCL12 in recurrence patients with HGG after operation, and WHO pathological grade IV, surgical resection range were incomplete resection are risk factor in recurrence patients with HGG after operation. Combine detection of SII, serum CXCL5, and CXCL12 has a high predictive value for recurrence in patients with HGG after operation. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的: 探讨全身免疫炎症指数 (SII) 联合血清 CXC 趋化因子配体 5 (CXCL5)、趋化因子配体 12 (CXCL12) 预测高级别脑胶 质瘤 (HGG) 患者术后复发的价值。方法: 选择 2019 年 1 月至 2022 年 1 月我院收治的 169 例行手术治疗的 HGG 患者。检测 HGG 患者中性粒细胞、淋巴细胞、血小板计数和血清 CXCL5、CXCL12 水平, 并计算术前 SII。术后随访 1 年, 根据术后复发情况将 HGG 患者分为复发组 (113 例) 和未复发组 (56 例)。多因素 Logistic 回归分析 HGG 患者术后复发的影响因素。受试者工作特征 (ROC) 曲线分析 SII 联合血清 CXCL5、CXCL12 预测 HGG 患者术后复发的价值。结果: 复发组 SII 和血清 CXCL5、CXCL12 水平 高于未复发组 (P＜0.05)。HGG 患者术后复发与年龄、术前 KPS 评分、WHO 病理分级、手术切除范围、术后治疗情况有关 (P＜ 0.05), 与性别无关 (P＞0.05)。多因素 Logistic 分析结果显示, WHO 病理分级Ⅳ级、手术切除范围为未全切, SII 升高和血清 CXCL5 升高、CXCL12 升高是 HGG 患者术后复发的危险因素 (P＜0.05)。SII、血清 CXCL5、CXCL12 单独检测预测 HGG 患者术后复 发的曲线下面积分别为 0.820、0.875、0.845, 联合检测预测曲线下面积为 0.964, 高于单独指标检测预测。结论: HGG 术后复发患者 的 SII 升高、血清 CXCL5 升高、CXCL12 升高, 且 WHO 病理分级Ⅳ级、手术切除范围为未全切是 HGG 患者术后复发的危险因 素, 联合检测 SII、血清 CXCL5、CXCL12 对 HGG 患者术后复发具有较高的预测价值。 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
