دورية أكاديمية
The sesquiterpenes with the COVID-19 Mpro inhibitory activity from the Carpesium abrotanoides L.
العنوان: | The sesquiterpenes with the COVID-19 Mpro inhibitory activity from the Carpesium abrotanoides L. |
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المؤلفون: | Fan, Yu-Wen, Ao, Zhuo-Yi, Zhang, Wei-Jie, Chen, Jia-Yan, Lian, Xin, Chen Pan, Yong-, Chen, Li-Ping, Wu, Jie-Wei, Yuan, Jie |
المصدر: | Natural Product Research; Jun2024, Vol. 38 Issue 11, p1909-1917, 9p |
مصطلحات موضوعية: | SESQUITERPENES, COVID-19, NUCLEAR magnetic resonance spectroscopy, PLANT extracts, COUMARINS |
مستخلص: | The extract of the whole plant of Carpesium abrotanoides L. yielded four new sesquiterpenes including a novel skeleton (claroguaiane A, 1), two guaianolides (claroguaianes B–C, 2–3), and one eudesmanolide (claroeudesmane A, 4), together with three known sesquiterpenoids (5–7). The structures of the new compounds were elucidated by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitive activity of COVID-19 Mpro. As a result, compound 5 showed moderate activity with an IC |
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قاعدة البيانات: | Complementary Index |
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