دورية أكاديمية
The effect of resolvin D1n‐3 DPA on primary oral epithelial cell migration in vitro.
| العنوان: | The effect of resolvin D1 |
|---|---|
| المؤلفون: | Balta, Maria G., Schreurs, Olav, Blix, Inger Johanne Schytte, Schenck, Karl |
| المصدر: | European Journal of Oral Sciences; Jun2024, Vol. 132 Issue 3, p1-7, 7p |
| مصطلحات موضوعية: | EPITHELIAL cells, WOUND healing, BIOLOGICAL models, IN vitro studies, CELL migration, BIOPSY, ANTI-inflammatory agents, RESEARCH funding, T-test (Statistics), CELL proliferation, CELL motility, ORAL mucosa, DESCRIPTIVE statistics, FLUORESCENT antibody technique, MICROBIOLOGICAL assay, ORGANIC compounds, STAINS & staining (Microscopy), DATA analysis software, SEQUENCE analysis, TUMOR necrosis factors, PHARMACODYNAMICS |
| مستخلص: | Specialized pro‐resolving lipid mediators (SPMs) are known for their anti‐inflammatory and pro‐resolving actions. The aim of the present study was to find new functions of the SPM resolvin D1n‐3 DPA (RvD1n‐3 DPA) on oral epithelial cells. As a starting point, we used a dataset obtained by RNA high‐throughput sequencing of oral epithelial cells exposed to TNF‐α and RvD1n‐3 DPA versus TNF‐α alone. GOrilla enrichment analysis showed that the actin cytoskeleton was significantly overrepresented after adjustment for multiple hypothesis testing. As actin, amongst others, is closely related to cell migration, we then explored whether RvD1n‐3 DPA can modulate oral epithelial cell migration. To this end, we used an in vitro cell migration model, including TNF‐α treatment, to mimic an inflammatory cell state. The analysis revealed that RvD1n‐3 DPA increased oral epithelial cell migration in the presence but not in the absence of TNF‐α. Addition of RvD1n‐3 DPA also induced F actin accumulation around the cell nucleus, indicating that RvD1n‐3 DPA potentially can mediate processes of intracellular transport. This indicates that this lipid mediator may be a promising therapeutic candidate in oral mucosal wound healing. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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