التفاصيل البيبلوغرافية
| العنوان: |
α‐Synuclein Pathology in PRKN‐Linked Parkinson's Disease: New Insights from a Blood‐Based Seed Amplification Assay. |
| المؤلفون: |
Kluge, Annika, Borsche, Max, Streubel‐Gallasch, Linn, Gül, Tuğçe, Schaake, Susen, Balck, Alexander, Prasuhn, Jannik, Campbell, Philip, Morris, Huw R., Schapira, Anthony H., Lohmann, Katja, Brüggemann, Norbert, Rakovic, Aleksandar, Seibler, Philip, Başak, A. Nazlı, Berg, Daniela, Klein, Christine |
| المصدر: |
Annals of Neurology; Jun2024, Vol. 95 Issue 6, p1173-1177, 5p |
| مصطلحات موضوعية: |
PARKINSON'S disease, ALPHA-synuclein, EXTRACELLULAR vesicles, SEEDS |
| مستخلص: |
Pathogenic variants in PRKN cause early‐onset Parkinson's disease (PD), while the role of alpha‐synuclein in PRKN‐PD remains uncertain. One study performed a blood‐based alpha‐synuclein seed amplification assay (SAA) in PRKN‐PD, not detecting seed amplification in 17 PRKN‐PD patients. By applying a methodologically different SAA focusing on neuron‐derived extracellular vesicles, we demonstrated alpha‐synuclein seed amplification in 8 of 13 PRKN‐PD patients, challenging the view of PRKN‐PD as a non‐synucleinopathy. Moreover, we performed blinded replication of the neuron‐derived extracellular vesicles‐dependent SAA in idiopathic PD patients and healthy controls. In conclusion, blood‐based neuron‐derived extracellular vesicles‐dependent SAA represents a promising biomarker to elucidate the underpinnings of (monogenic) PD. ANN NEUROL 2024;95:1173–1177 [ABSTRACT FROM AUTHOR] |
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