دورية أكاديمية
Oxidized glutathione reverts carbapenem resistance in blaNDM-1-carrying Escherichia coli.
| العنوان: | Oxidized glutathione reverts carbapenem resistance in bla |
|---|---|
| المؤلفون: | Ye, Dongyang, Li, Xiaowei, Zhao, Liang, Liu, Saiwa, Jia, Xixi, Wang, Zhinan, Du, Jingjing, Ge, Lirui, Shen, Jianzhong, Xia, Xi |
| المصدر: | EMBO Molecular Medicine; May2024, Vol. 16 Issue 5, p1051-1062, 12p |
| مستخلص: | The emergence of drug-resistant Enterobacteriaceae carrying plasmid-mediated β-lactamase genes has become a significant threat to public health. Organisms in the Enterobacteriaceae family containing New Delhi metallo-β-lactamase‑1 (NDM-1) and its variants, which are capable of hydrolyzing nearly all β-lactam antibacterial agents, including carbapenems, are referred to as superbugs and distributed worldwide. Despite efforts over the past decade, the discovery of an NDM-1 inhibitor that can reach the clinic remains a challenge. Here, we identified oxidized glutathione (GSSG) as a metabolic biomarker for bla |
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| قاعدة البيانات: | Complementary Index |
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