دورية أكاديمية
Molecular two-point recognition of fructosyl valine and fructosyl glycyl histidine in water by fluorescent Zn(II)-terpyridine complexes bearing boronic acids.
العنوان: | Molecular two-point recognition of fructosyl valine and fructosyl glycyl histidine in water by fluorescent Zn(II)-terpyridine complexes bearing boronic acids. |
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المؤلفون: | Salomón-Flores, María K., Valdes-García, Josue, Viviano-Posadas, Alejandro O., Martínez-Otero, Diego, Barroso-Flores, Joaquín, Bazany-Rodríguez, Iván J., Dorazco-González, Alejandro |
المصدر: | Dalton Transactions: An International Journal of Inorganic Chemistry; 5/28/2024, Vol. 53 Issue 20, p8692-8708, 17p |
مصطلحات موضوعية: | MOLECULAR recognition, HISTIDINE, BORONIC acids, DIPYRRINS, PHOTOINDUCED electron transfer, BIOCHEMISTRY, VALINE |
مستخلص: | Selective recognition of fructosyl amino acids in water by arylboronic acid-based receptors is a central field of modern supramolecular chemistry that impacts biological and medicinal chemistry. Fructosyl valine (FV) and fructosyl glycyl histidine (FGH) occur as N-terminal moieties of human glycated hemoglobin; therefore, the molecular design of biomimetic receptors is an attractive, but very challenging goal. Herein, we report three novel cationic Zn-terpyridine complexes bearing a fluorescent N-quinolinium nucleus covalently linked to three different isomers of strongly acidified phenylboronic acids (ortho-, 2Zn; meta-, 3Zn and para-, 4Zn) for the optical recognition of FV, FGH and comparative analytes (D -fructose, Gly, Val and His) in pure water at physiological pH. The complexes were designed to act as fluorescent receptors using a cooperative action of boric acid and a metal chelate. Complex 3Zn was found to display the most acidic –B(OH) |
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قاعدة البيانات: | Complementary Index |
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