التفاصيل البيبلوغرافية
| العنوان: |
Relationship between atherogenic index of plasma, asprosin, and metrnl levels in hemodialysis patients. |
| المؤلفون: |
Yardim, Meltem, Deniz, Levent, Saltabas, Mehmet Akif, Kayalp, Damla, Akkoc, Ramazan Fazil, Kuloglu, Tuncay |
| المصدر: |
International Journal of Medical Biochemistry; 2024, Vol. 7 Issue 2, p60-66, 7p |
| مصطلحات موضوعية: |
HEMODIALYSIS patients, CHRONIC kidney failure, BLOOD plasma, BODY mass index, BLOOD sampling, CARDIOVASCULAR diseases risk factors |
| مستخلص: |
Objectives: This study aimed to evaluate the relationship between the atherogenic index of plasma (AIP) and plasma asprosin and metrnl levels in hemodialysis (HD) patients. Methods: Forty-eight patients receiving HD treatment with a diagnosis of end-stage renal disease (ESRD) were included. The control group comprised 34 age-, sex-, and body mass index-matched healthy volunteers without a history of renal disease. ESRD patients were divided into two groups: high-risk (AIP≥0.24) and low-moderate risk (AIP<0.24). Asprosin and metrnl levels in the plasma of blood samples taken just before dialysis were studied by enzyme-linked immunosorbent assay. Results: A significant difference was found between the control group [23.3(19.9-27.7 ng/mL)], the low-moderate risk group [39.3(34.9-40.8 ng/mL)], and the high-risk group [48.1(44.5-49.9 ng/mL)] in terms of asprosin levels (for each p<0.001). Asprosin values of both low-moderate risk and high-risk groups were significantly higher than the controls. In the high-risk group, plasma asprosin levels were higher than in the low-moderate risk group (p=0.012). Metrnl levels of the high-risk group were found to be lower than both the control and low-risk groups (p<0.001 and p=0.003, respectively). AIP showed a positive relation to asprosin and a negative relation to metrnl. Conclusion: Logistic regression analysis has revealed important insights into the independent relationships between metrnl, asprosin, and high AIP values in HD patients. These findings support the anti-atherogenic potential of metrnl and suggest the potential atherogenic effects of asprosin, highlighting the complex interplay between adipokines and cardiovascular risk in this patient population. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Medical Biochemistry is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder