التفاصيل البيبلوغرافية
| العنوان: |
18β-glycyrrhetinic acid alleviates radiation-induced skin injury by activating the Nrf2/HO-1 signaling pathway. |
| المؤلفون: |
Wang, Zeng, Chen, Ruiqing, Chen, Junying, Su, Li |
| المصدر: |
Biological Chemistry; Jun2024, Vol. 405 Issue 6, p407-415, 9p |
| مصطلحات موضوعية: |
SKIN injuries, CELLULAR signal transduction, RADIODERMATITIS, RADIOTHERAPY complications, LICORICE (Plant) |
| مستخلص: |
Radiation-induced skin injury is a common side effect of radiotherapy, but there are few therapeutic drugs available for prevention or treatment. In this study, we demonstrate that 18β-Glycyrrhetinic acid (18β-GA), a bioactive component derived from Glycyrrhiza glabra, substantially reduces the accumulation of reactive oxygen species (ROS) and inhibits apoptosis in HaCaT cells after ionizing radiation (IR), thereby mitigating radiation-induced skin injury. Mechanistically, 18β-GA promotes the nuclear import of Nrf2, leading to activation of the Nrf2/HO-1 signaling pathway in response to IR. Importantly, Nrf2 silencing increases cell apoptosis and reverse the protective effect of 18β-GA on radiation-induced skin injury. Furthermore, 18β-GA preserves skin tissue structure after irradiation, inhibits inflammatory cell infiltration, and alleviates radiation dermatitis. In conclusion, our results suggest that 18β-GA reduces intracellular ROS production and apoptosis by activating the Nrf2/HO-1 signaling pathway, leading to amelioration of radiation dermatitis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
