التفاصيل البيبلوغرافية
| العنوان: |
Phytochemical Screening and Antidiabetic Activity of Aqueous Extract of Evolvulus Alsinoides Leaves: An In Vitro and In Silico Study. |
| المؤلفون: |
S., Tarun Mukundh, Veeraraghavan, Vishnu Priya, Ponnusamy, Bhuvaneswari, Jayaraman, Selvaraj |
| المصدر: |
Journal of Pharmacy & Bioallied Sciences; 2024 Supplement, Vol. 16, pS1246-S1248, 3p |
| مصطلحات موضوعية: |
AMYLASES, MOLECULAR docking, ALPHA-glucosidases, HYPOGLYCEMIC agents, CAFFEIC acid, FOOD habits, ALPHA-amylase |
| مستخلص: |
Background: Nowadays, diabetes mellitus has become common worldwide due to changes in lifestyle, sedentary life, alterations in food habits, and other genetic and environmental factors. It is necessary to create awareness about the growing pandemic. Aim: To evaluate the antidiabetic potential of Evolvulus alsinoides. Methods: In vitro a-amylase inhibition and a-glucosidase inhibition activity. Molecular docking analysis. Results: The plant is rich in naturally occurring phytocompound. The results of the study showed that E. alsinoides has the potential to inhibit the activity of alpha-amylase and alpha-glucosidase. Moreover, this result was validated using in silico molecular docking studies that showed a good binding affinity of one of the major phytocompound, caffeic acid, with molecules in the insulin signaling cascade. Conclusion: E. alsinoides has a potent antidiabetic activity and can be further employed in animal and human studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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