التفاصيل البيبلوغرافية
العنوان: |
L-LOP/LOPP for the treatment of canine gastrointestinal/ hepatosplenic lymphoma. |
المؤلفون: |
Yu Ying Lai, Horta, Rodrigo dos Santos, Almendros, Angel, Ha, Patrick W. Y., Giuliano, Antonio |
المصدر: |
Frontiers in Veterinary Science; 2024, p01-08, 8p |
مصطلحات موضوعية: |
LYMPHOMAS, PROGRESSION-free survival, SURVIVAL rate, MAST cell tumors, MEDICAL protocols, PROGNOSIS |
مستخلص: |
Canine gastrointestinal (GI) and hepatosplenic (HS) high-grade (large cell) lymphomas are uncommon forms of canine lymphomas, with a very poor response to chemotherapy and a very poor prognosis. Currently, there are no established effective chemotherapy protocols for canine GI/HS lymphomas. This case series aimed to retrospectively evaluate the efficacy of lomustine-based protocols L-LOP (L-asparaginase, lomustine, vincristine, and prednisolone) and L-LOPP (with the addition of procarbazine) for treatment of canine GI/ HS lymphomas. Medical records of dogs with cytologically or histologically diagnosed lymphoma at CityU Veterinary Medical Centre from 2019 to 2022 were retrospectively reviewed. The L-LOP/LOPP treatment protocol was well tolerated with rare severe adverse events. Median progression-free survival for GI and HS lymphoma was 56 days (range, 10-274 days) and 57 days (range 8-135 days) respectively; while median survival time for GI and HS lymphoma was 93 days (range 10-325 days) and 210 days (range 8-240 days) respectively. [ABSTRACT FROM AUTHOR] |
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قاعدة البيانات: |
Complementary Index |