التفاصيل البيبلوغرافية
| العنوان: |
Pulmonary arterial hypertension treatment: an individual participant data network meta-analysis. |
| المؤلفون: |
Moutchia, Jude, McClelland, Robyn L, Al-Naamani, Nadine, Appleby, Dina H, Holmes, John H, Minhas, Jasleen, Mazurek, Jeremy A, Palevsky, Harold I, Ventetuolo, Corey E, Kawut, Steven M |
| المصدر: |
European Heart Journal; 6/1/2024, Vol. 45 Issue 21, p1937-1952, 16p |
| مصطلحات موضوعية: |
PULMONARY arterial hypertension, TREATMENT effect heterogeneity, CORONARY artery disease, BODY mass index, CLINICAL trials, INTERMITTENT claudication, PULMONARY hypertension |
| مستخلص: |
Background and Aims: Effective therapies that target three main signalling pathways are approved to treat pulmonary arterial hypertension (PAH). However, there are few large patient-level studies that compare the effectiveness of these pathways. The aim of this analysis was to compare the effectiveness of the treatment pathways in PAH and to assess treatment heterogeneity. Methods: A network meta-analysis was performed using individual participant data of 6811 PAH patients from 20 Phase III randomized clinical trials of therapy for PAH that were submitted to the US Food and Drug Administration. Individual drugs were grouped by the following treatment pathways: endothelin, nitric oxide, and prostacyclin pathways. Results: The mean (±standard deviation) age of the sample was 49.2 (±15.4) years; 78.4% were female, 59.7% had idiopathic PAH, and 36.5% were on background PAH therapy. After covariate adjustment, targeting the endothelin + nitric oxide pathway {β: 43.7 m [95% confidence interval (CI): 32.9, 54.4]}, nitric oxide pathway [β: 29.4 m (95% CI: 22.6, 36.3)], endothelin pathway [β: 25.3 m (95% CI: 19.8, 30.8)], and prostacyclin pathway [oral/inhaled β: 19.1 m (95% CI: 14.2, 24.0), intravenous/subcutaneous β: 24.4 m (95% CI: 15.1, 33.7)] significantly increased 6 min walk distance at 12 or 16 weeks compared with placebo. Treatments also significantly reduced the likelihood of having clinical worsening events. There was significant heterogeneity of treatment effects by age, body mass index, hypertension, diabetes, and coronary artery disease. Conclusions: Drugs targeting the three traditional treatment pathways significantly improve outcomes in PAH, with significant treatment heterogeneity in patients with some comorbidities. Randomized clinical trials are warranted to identify the most effective treatment strategies in a personalized approach. Structured Graphical Abstract Comparison of the effectiveness and heterogeneity of treatment effects in pulmonary arterial hypertension. 6MWD, 6 min walk distance; CI, confidence interval; IV/Sc, intravenous/subcutaneous; PO/Inh, oral/inhaled. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Heart Journal is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder