التفاصيل البيبلوغرافية
| العنوان: |
Clinical analysis between serum 25-hydroxyvitamin D3, interleukin-6 levels and febrile convulsion in children. (English) |
| المؤلفون: |
LI Bang-tao, PANG Qi-ming, XIAO Mei-fang, HUANG Yan, LI Hong-ai, WANG Cui, ZHANG Su-li, ZHANG Hua-ling, XIANG Wei |
| المصدر: |
Journal of Hainan Medical University; 2023, Vol. 29 Issue 10, p751-756, 6p |
| مصطلحات موضوعية: |
FEBRILE seizures, BLOOD serum analysis, INTERLEUKIN-6 |
| مصطلحات جغرافية: |
HAINAN Sheng (China) |
| مستخلص: |
Objective: To investigate the relation between febrile convulsions and 25-hydroxyvitamin D3[25-(OH)D3 and interleukin-6 (IL-6) levels in children. Methods: 241 children (divided into simple febrile convulsions and complex febrile convulsions), who were diagnosed with febrile convulsions at the Hainan Women and Children's Medical Center from January 2017 to October 2022, were selected into the febrile convulsions group; 100 healthy children, who had no uncomfortable symptoms and attended the outpatient clinic of the Hainan Women and Children's Medical Center for physical examination, were included into the control group. For all the subjects, the serum 25-(OH)D3 and IL-6 levels were measured, and clinical information, such as age, gender and season, was recorded. Results: (1)Serum 25-(OH)D3 levels in the febrile convulsion group were significantly lower than in the healthy control group [(78.77 ± 20.37) nmol/L versus (96.55 ± 29.74) nmol/L, respectively], and there was a statistically significance between the two groups (t=-6.359, P<0.001). Serum IL-6 levels in the febrile convulsion group were significantly higher than in the healthy control group, and there was a statistically significance between the two groups (Z=-14.291, P<0.001). (2)Serum 25-(OH)D3 levels in children with complex febrile convulsions were significantly lower than those in children with simple febrile convulsions, and the difference between the two groups was statistically significant (t= of 6.612, P<0.05). IL-6 levels were higher in children with complex febrile convulsions than in children with simple febrile convulsions, and the difference between the two groups was statistically significant (Z= - 10.151, P<0.001). The difference in the severity of febrile convulsions was statistically significant in serum 25- (OH)D3 levels (χ²=29.83, P<0.001). (3)The results of correlation analysis showed that serum 25-(OH) D3 level was negatively correlated with febrile convulsion (γ=-0.393, P<0.05). However, serum IL-6 levels were positively correlated with it (γs=0.328, P<0.05). (4)In contrast, there was no statistically significant difference in serum 25-(OH)D3 levels among children with febrile convulsions in different seasons (P>0.05). Conclusion: There is a correlation between febrile convulsion and serum levels of 25 - (OH) D3 and IL-6. 25-(OH)D3 and IL-6 may participate in the pathogenesis of febrile convulsion. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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