دورية أكاديمية
In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae).
العنوان: | In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae). |
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المؤلفون: | Feunaing, Romeo Toko, Tamfu, Alfred Ngenge, Gbaweng, Abel Joel Yaya, Kucukaydin, Selcuk, Tchamgoue, Joseph, Lannang, Alain Meli, Lenta, Bruno Ndjakou, Kouam, Simeon Fogue, Duru, Mehmet Emin, Anouar, El Hassane, Talla, Emmanuel, Dinica, Rodica Mihaela |
المصدر: | Molecules; Jun2024, Vol. 29 Issue 11, p2456, 19p |
مصطلحات موضوعية: | MOLECULAR docking, GLYCOSIDASE inhibitors, TERMINALIA, COMBRETACEAE, ELLAGIC acid, SHIKIMIC acid, ACETYLCHOLINESTERASE, ALPHA-glucosidases |
مستخلص: | Alzheimer's disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are suitable therapies for AD, while α-amylase and α-glucosidase inhibitors are employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera and evaluated for their AChE, BChE, α-amylase, and α-glucosidase inhibitions. From 1H and 13C NMR data, the compounds were identified as 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-xylopyranoside (2), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-glucopyranoside (3), 3,3′-di-O-methyl ellagic acid-4-O-β-D-glucopyranoside (4), myricetin-3-O-rhamnoside (5), shikimic acid (6), arjungenin (7), terminolic acid (8), 24-deoxysericoside (9), arjunglucoside I (10), and chebuloside II (11). The derivatives of ellagic acid (1–4) showed moderate to good inhibition of cholinesterases, with the most potent being 3,3′-di-O-methyl ellagic acid, with IC |
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قاعدة البيانات: | Complementary Index |
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