التفاصيل البيبلوغرافية
| العنوان: |
Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation. |
| المؤلفون: |
Natalini, Jake G., Wong, Kendrew K., Nelson, Nathaniel C., Wu, Benjamin G., Rudym, Darya, Lesko, Melissa B., Qayum, Seema, Lewis, Tyler C., Wong, Adrian, Chang, Stephanie H., Chan, Justin C. Y., Geraci, Travis C., Li, Yonghua, Wang, Chan, Li, Huilin, Pamar, Prerna, Schnier, Joseph, Mahoney, Ian J., Malik, Tahir, Darawshy, Fares |
| المصدر: |
American Journal of Respiratory & Critical Care Medicine; 6/15/2024, Vol. 209 Issue 12, p1463-1476, 14p |
| مصطلحات موضوعية: |
GRAFT rejection, LUNG transplantation, HOMOGRAFTS |
| مستخلص: |
Rationale: Acute cellular rejection (ACR) after lung transplant is a leading risk factor for chronic lung allograft dysfunction. Prior studies have demonstrated dynamic microbial changes occurring within the allograft and gut that influence local adaptive and innate immune responses. However, the lung microbiome's overall impact on ACR risk remains poorly understood. Objectives: To evaluate whether temporal changes in microbial signatures were associated with the development of ACR. Methods: We performed cross-sectional and longitudinal analyses (joint modeling of longitudinal and time-to-event data and trajectory comparisons) of 16S rRNA gene sequencing results derived from lung transplant recipient lower airway samples collected at multiple time points. Measurements and Main Results: Among 103 lung transplant recipients, 25 (24.3%) developed ACR. In comparing samples acquired 1 month after transplant, subjects who never developed ACR demonstrated lower airway enrichment with several oral commensals (e.g., Prevotella and Veillonella spp.) than those with current or future (beyond 1 mo) ACR. However, a subgroup analysis of those who developed ACR beyond 1 month revealed delayed enrichment with oral commensals occurring at the time of ACR diagnosis compared with baseline, when enrichment with more traditionally pathogenic taxa was present. In longitudinal models, dynamic changes in α-diversity (characterized by an initial decrease and a subsequent increase) and in the taxonomic trajectories of numerous oral commensals were more commonly observed in subjects with ACR. Conclusions: Dynamic changes in the lower airway microbiota are associated with the development of ACR, supporting its potential role as a useful biomarker or in ACR pathogenesis. [ABSTRACT FROM AUTHOR] |
|
Copyright of American Journal of Respiratory & Critical Care Medicine is the property of American Thoracic Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
