دورية أكاديمية
Click synthesis of novel 6-((1H-1,2,3-triazol-4-yl)methyl)-6H-indolo[2,3-b]quinoxalines for in vitro anticancer evaluation and docking studies.
العنوان: | Click synthesis of novel 6-((1H-1,2,3-triazol-4-yl)methyl)-6H-indolo[2,3-b]quinoxalines for in vitro anticancer evaluation and docking studies. |
---|---|
المؤلفون: | El Malah, Tamer, El-Rashedy, Ahmed A., Hegab, Mohamed Ibrahim, Awad, Hanem M., Shamroukh, Ahmed Hussien |
المصدر: | New Journal of Chemistry; 6/28/2024, Vol. 48 Issue 24, p11064-11078, 15p |
مصطلحات موضوعية: | MOLECULAR docking, QUINOXALINES, CELL cycle, MOLECULAR dynamics, CHEMICAL synthesis |
مستخلص: | Herein, we report the design and synthesis of a novel series of 6-((1H-1,2,3-triazol-4-yl)methyl)-6H-indolo[2,3-b]quinoxalines (22–29) via the copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction. The target compounds formed through two pathways (A and B). The structures of the newly click synthesised 1,2,3-triazole-6H-indolo[2,3-b]quinoxalines (22–29) were confirmed on the basis of their elemental analysis and spectral data. Some of these compounds exhibited significant antiproliferative effects against tested cancer cells, including hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7), and colon cancer (HCT116), relative to healthy noncancerous control skin fibroblast cells (BJ-1) to evaluate their cytotoxic effects. Among the tested compounds, compound 27 exhibited strong activity with IC |
Copyright of New Journal of Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Complementary Index |
كن أول من يترك تعليقا!