التفاصيل البيبلوغرافية
| العنوان: |
Spontaneous Lethal Outbreak of Influenza A Virus Infection in Vaccinated Sows on Two Farms Suggesting the Occurrence of Vaccine-Associated Enhanced Respiratory Disease with Eosinophilic Lung Pathology. |
| المؤلفون: |
Reineking, Wencke, Hennig-Pauka, Isabel, Schröder, Ludger, Höner, Ulf, Schreiber, Elena, Geiping, Lukas, Lassnig, Simon, Bonilla, Marta C., Hewicker-Trautwein, Marion, de Buhr, Nicole |
| المصدر: |
Viruses (1999-4915); Jun2024, Vol. 16 Issue 6, p955, 22p |
| مصطلحات موضوعية: |
LUNGS, VIRUS diseases, INFLUENZA A virus, RESPIRATORY diseases, INFLUENZA viruses, SOWS, MATERNALLY acquired immunity, EOSINOPHILIC granuloma |
| مستخلص: |
Influenza A virus (IAV) infections in swine are usually subclinical, but they can reach high morbidity rates. The mortality rate is normally low. In this study, six vaccinated, spontaneously deceased sows revealed IAV infection and enhanced neutrophilic bronchopneumonia with unexpectedly large numbers of infiltrating eosinophils. The purpose of this study was to characterize these lung lesions with special emphasis on the phenotypes of inflammatory cells, the presence of eosinophilic peroxidase (EPO), and neutrophil extracellular traps (NETs). The number of Sirius red-stained eosinophils was significantly higher in the lungs of IAV-infected sows compared to healthy pigs, indicating a migration of eosinophils from blood vessels into the lung tissue stimulated by IAV infection. The detection of intra- and extracellular EPO in the lungs suggests its contribution to pulmonary damage. The presence of CD3+ T lymphocytes, CD20+ B lymphocytes, and Iba-1+ macrophages indicates the involvement of cell-mediated immune responses in disease progression. Furthermore, high numbers of myeloperoxidase-positive cells were detected. However, DNA-histone-1 complexes were reduced in IAV-infected sows, leading to the hypothesis that NETs are not formed in the IAV-infected sows. In conclusion, our findings in the lungs of IAV-infected vaccinated sows suggest the presence of so far unreported field cases of vaccine-associated enhanced respiratory disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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