دورية أكاديمية
CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
| العنوان: | CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age. |
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| المؤلفون: | Menon, Tejas, Illing, Patricia T., Chaurasia, Priyanka, McQuilten, Hayley A., Shepherd, Chloe, Rowntree, Louise C., Petersen, Jan, Littler, Dene R., Khuu, Grace, Ziyi Huang, Allen, Lilith F., Rockman, Steve, Crowe, Jane, Flanagan, Katie L., Wakim, Linda M., Nguyen, Thi H. O., Mifsud, Nicole A., Rossjohn, Jamie, Purcell, Anthony W., van de Sandt, Carolien E. |
| المصدر: | Nature Communications; 4/29/2024, Vol. 15 Issue 1, p1-21, 21p, 1 Diagram, 1 Chart, 7 Graphs |
| مستخلص: | Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is needed to develop effective cross-reactive T-cell based IBV vaccines. Here we identify 9 highly conserved IBV CD8+ T-cell epitopes restricted to HLA-B*07:02, HLA-B*08:01 and HLA-B*35:01. Memory IBVspecific tetramer+ CD8+ T-cells are present within blood and tissues. Frequencies of IBV-specific CD8+ T-cells decline with age, but maintain a central memory phenotype. HLA-B*07:02 and HLA-B*08:01-restricted NP |
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| قاعدة البيانات: | Complementary Index |
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