التفاصيل البيبلوغرافية
| العنوان: |
11-Hydroxy-7-Methoxy-2,8-Dimethyltetracene-5,12-Dione. |
| المؤلفون: |
Astakala, Rishi Vachaspathy, Preet, Gagan, Haj Hasan, Ahlam, Desai, Ria, Asenjo, Juan A., Andrews, Barbara, Harrison, William T. A., Ebel, Rainer, Jaspars, Marcel |
| المصدر: |
Molbank; Jun2024, Vol. 2024 Issue 2, pM1822, 8p |
| مصطلحات موضوعية: |
X-ray crystallography, CHEMICAL yield, CRYPTOCOCCUS neoformans, ANTI-infective agents, BIOMES |
| مصطلحات جغرافية: |
ATACAMA Desert (Chile), CHILE |
| مستخلص: |
Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new reduced anthracycline-related compound from the Atacama Desert-derived bacterium Saccharothrix S26. Structural characterisation was achieved by one-dimensional and two-dimensional NMR, HR-LCMS, and X-ray crystallography. The compound was tested against the ESKAPE pathogens, bovine mastitis-related pathogens, and the fungal strain Cryptococcus neoformans, but no antimicrobial activity was observed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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