التفاصيل البيبلوغرافية
| العنوان: |
Predictors of functional outcome after stroke: Sex differences in older individuals. |
| المؤلفون: |
Mavridis, Anastasios, Reinholdsson, Malin, Sunnerhagen, Katharina S., Abzhandadze, Tamar |
| المصدر: |
Journal of the American Geriatrics Society; Jul2024, Vol. 72 Issue 7, p2100-2110, 11p |
| مصطلحات موضوعية: |
STROKE treatment, CROSS-sectional method, STROKE units, DISABILITIES, GOODNESS-of-fit tests, STATISTICAL models, RESEARCH funding, THROMBOLYTIC therapy, ACADEMIC medical centers, SEX distribution, SCIENTIFIC observation, FUNCTIONAL status, TREATMENT effectiveness, HEMORRHAGIC stroke, MANN Whitney U Test, ODDS ratio, ISCHEMIC stroke, ATRIAL fibrillation, STROKE rehabilitation, STROKE patients, THROMBECTOMY, CONFIDENCE intervals, CEREBRAL infarction, DATA analysis software, STROKE, REGRESSION analysis, TRANSIENT ischemic attack, EVALUATION, OLD age |
| مصطلحات جغرافية: |
SWEDEN |
| مستخلص: |
Background: Sex differences in stroke are well documented, with females being older at onset, with more severe strokes and worse outcomes than males. Females receive less comprehensive stroke unit treatment. Similarly, older individuals receive poorer quality care than younger ones. There is limited research on sex differences in factors that impact 3‐month poststroke functional outcome in people older than 80 years. Methods: This register‐based and cross‐sectional study analyzed data from two stroke quality registers in Sweden from 2014 through 2019. The study included patients aged ≥80 with a diagnosis of ischemic or hemorrhagic stroke. Sociodemographic features, prestroke condition, stroke severity on admission (National Institutes of Health Stroke Scale [NIHSS]), stroke unit care, rehabilitation plans, and 3‐month poststroke functional outcome measured with the modified Rankin Scale were analyzed. Ordinal regression analyses stratified by sex were conducted to assess sex differences in factors that impact poststroke functional outcome 3 months after the stroke. Results: A total of 2245 patients were studied with the majority (59.2%) being females. Females experienced more severe strokes (NIHSS median 4 vs. 3, p = 0.01) and were older at stroke onset than males (87.0 vs. 85.4, p < 0.001). Females were also less independent prestroke (69.9% vs. 77.4%, p < 0.001) and a higher proportion of females lived alone (78.2% vs. 44.2%, p < 0.001). Males received intravenous thrombolysis more often than females (16.3% vs. 12.0%, p = 0.005). Regarding 3‐month functional outcome, males benefited more from thrombolysis (odds ratio [OR] 0.52, 95% confidence interval [CI] 0.30–0.83), whereas females benefited more from thrombectomy (OR 0.40, 95% CI 0.20–0.71). Conclusion: Stroke care should be adapted to sex disparities in older individuals, while clinicians should be aware of these sex disparities. Further research could clarify the mechanisms behind these disparities and lead to a more personalized approach to stroke care of the older population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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