دورية أكاديمية
Clinical Features and Genomic Epidemiology of Bloodstream Infections due to Enterococcal Species Other Than Enterococcus faecalis or E. faecium in Patients With Cancer.
| العنوان: | Clinical Features and Genomic Epidemiology of Bloodstream Infections due to Enterococcal Species Other Than Enterococcus faecalis or E. faecium in Patients With Cancer. |
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| المؤلفون: | Axell-House, Dierdre B, Ashley, Patrycja A, Egge, Stephanie L, Tran, Truc T, Pedroza, Claudia, Zhang, Meng, Dinh, An Q, Simar, Shelby R, Sahasrabhojane, Pranoti V, Miller, William R, Shelburne, Samuel A, Hanson, Blake M, Arias, Cesar A |
| المصدر: | Open Forum Infectious Diseases; Jun2024, Vol. 11 Issue 6, p1-9, 9p |
| مصطلحات موضوعية: | ENTEROCOCCUS, ENTEROCOCCAL infections, ENTEROCOCCUS faecalis, CANCER patients, WHOLE genome sequencing, HEMATOLOGIC malignancies, INTRA-abdominal pressure |
| مستخلص: | Background Non– Enterococcus faecium, non– E. faecalis (NFF) enterococci are a heterogeneous group of clinically pathogenic enterococci that include species with intrinsic low-level vancomycin resistance. Patients with cancer are at increased risk for bacteremia with NFF enterococci, but their clinical and molecular epidemiology have not been extensively described. Methods We conducted a retrospective review of all patients (n = 70) with NFF bacteremia from 2016 to 2022 at a major cancer center. The main outcomes assessed were 30-day mortality, microbiological failure (positive blood cultures for ≥4 days), and recurrence of bacteremia (positive blood culture <14 days after clearance). Whole-genome sequencing was performed on all available NFF (n = 65). Results Patients with hematological malignancies made up 56% of the cohort (77% had leukemia). The majority of solid malignancies (87%) were gastrointestinal in origin. The majority of infections (83%) originated from an intra-abdominal source. The most common NFF species were E. gallinarum (50%) and E. casseliflavus (30%). Most (61%) patients received combination therapy. Bacteremia recurred in 4.3% of patients, there was a 30-day mortality of 23%, and 4.3% had microbiological failure. E. gallinarum and E. casseliflavus isolates were genetically diverse with no spatiotemporal clustering to suggest a single strain. Frequencies of ampicillin resistance (4.3%) and daptomycin resistance (1.9%) were low. Patients with hematologic malignancy had infections with NFF enterococci that harbored more resistance genes than patients with solid malignancy (P =.005). Conclusions NFF bacteremia is caused by a heterogeneous population of isolates and is associated with significant mortality. Hematological malignancy is an important risk factor for infection with NFF resistant to multiple antibiotics. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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