دورية أكاديمية
Clinical value of joint detection of cerebrospinal fluid and blood routine indicators in differentiating between multiple gliomas and primary central nervous system lymphoma.
| العنوان: | Clinical value of joint detection of cerebrospinal fluid and blood routine indicators in differentiating between multiple gliomas and primary central nervous system lymphoma. (English) |
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| المؤلفون: | JIANG Hua, ZHANG Limin, WANG Dan, HAN Ping, SUN Yuehong, LI Yuwen, ZHANG Chenxi, JIANG Wencan, LI Xiao, ZHAO Hui |
| المصدر: | Journal of Practical Medicine / Shiyong Yixue Zazhi; 7/10/2024, Vol. 40 Issue 13, p1864-1873, 6p |
| مصطلحات موضوعية: | CEREBROSPINAL fluid, CENTRAL nervous system, GLIOMAS, LYMPHOCYTE count, EOSINOPHILS |
| مستخلص: | Objective To investigate the clinical significance of combined cerebrospinal fluid (CSF) and routine blood parameter analysis in differentiating between multiple cerebral glioma (MCG) and primary central nervous system lymphoma (PCNSL) . Methods We Rretrospectively analyzed the clinical data, CSF and routine blood indicators levels of 62 MCG patients and 56 PCNSL patients admitted to Beijing Tiantan Hospital, Capital Medical University from November 2017 to March 2023. Additionally, we assessed the diagnostic value of individual meaningful indicators as well as their combinations in distinguishing between MCG and PCNSL. Results The levels of CSF total cell count, CSF white cell count, CSF: pro, lactate, routine bloodperipheral neutrophil count, and neutrophil percentage were significantly higher in the MCG group than in the PCNSL group (P < 0.05) ; while the levels of CSF: Glu, CSF: cl, routine blood lymphocyte count, eosinophil, lymphocyte percentage, and eosinophil percentage were significantly higher in the PCNSL group than in the MCG group (P < 0.05) . The AUCs of CSF cell count, CSF white cell count, CSF: pro, lactate, routine blood neutrophil count, neutrophil percentage for differentiating MCG from PCNSL were 0.900, 0.899, 0.797, 0.867, 0.828 and 0.772 respectively; sensitivities were 72.4%, 77.6%, 63.8%, 67.2%, 72.4%, 82.8%, 77.6% and 81%, with sensitivities of 97.1%, 100%, 88.2%, 91.2%, 88.2%, 64.7%, 100% and 94.1%, respectively. In addition, the combined detection of CSF total cell count, CSF white cell count, CSF: pro, routine blood neutrophil count and neutrophil percentage in CSF had an AUC of 0.919 for differentiating MCG from PCNSL, with a sensitivity and specificity of 77.6% and 100%, respectively. Conclusions Combined detection of CSF indicators including CSF total cell count, CSF white cell count, CSF: pro, along with routine blood markers such as neutrophil count and neutrophil percentage, holds significant clinical utility for differentiating between MCG and PCNSL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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