التفاصيل البيبلوغرافية
| العنوان: |
Synthesis, Characterisation, and Antibacterial Activities of Cu(I) Complexes Bearing (N^N) Bidentate Schiff Bases having Triphenylphosphine Ancillary Ligand. |
| المؤلفون: |
S. O., ODULAJA, A. A., ADELEKE, S. A., AMOLEGBE, N. O., SANYAOLU, S. T., YUSSUF, A. M., HASHIMI |
| المصدر: |
FUPRE Journal of Scientific & Industrial Research; 2024, Vol. 8 Issue 3, p175-187, 13p |
| مصطلحات موضوعية: |
ANTIBACTERIAL agents, TRIPHENYLPHOSPHINE, SCHIFF bases, METAL complexes, DRUG design, ORTHORHOMBIC crystal system |
| مستخلص: |
This work synthesized new biologically active Cu(I) complexes 1-5, obtained from the reaction of Cu(I) nitrate with different bidentate pyridinyl Schiff base ligands (E)1-(pyridin-2-yl)-N-(p-tolyl)methanimine L1, (E)-1-(pyridin-2-yl)-N-(otolyl) methanimine L2, (E)-N-isopropyl-1-(pyridine-2-yl)methanimine L3, (E)-Nmesityl-(pyridinyl)methanimine L4 and (E)-N-(2,6-dimethylphenyl)-1-(pyridine-2-yl)methanimine L5, with PPh3 ancillary ligand. The metal complexes with general formula [Cu L(PPh3)2]NO3, were characterised by FT-IR, UV-Vis, NMR and MS, X-ray crystallography and elemental analysis. The antibacterial activities against Staphylococcus aureus (SA), Escherichia coli (EC), Klebsiella pneumonia and Pseudomonas aeruginosa (PA) were investigated using agar well diffusion method with ofloxacin as reference. UV-Visible spectra and FT-IR result showed bathochromic shift in the imino (C=N) frequencies in the complexes confirming coordination to the metal centre. Single crystals obtained in complexes 2, 3, 5 revealed orthorhombic crystal systems having Tau (t4) values in the range 0.73 - 0.87 depicting distorted tetrahedral geometries. Coordination to the metal center was bidentate for all the ligands via the pyridinyl N and imine N in conjunction with two triphenylphosphine P in the N^N^P^P fashion in complexes 2, 3, and N^N^P^O fashion in complex 5. The antibacterial activities revealed that all the complexes exhibited better antibacterial activities relative to their parent ligands and PPh3. The study found out that the newly synthesized complexes have better antibacterial performances hence make the metal complexes potential chemotherapeutic agents in drug design. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
