دورية أكاديمية
أعرض في EDS

Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid.

التفاصيل البيبلوغرافية
العنوان: Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid.
المؤلفون: Chang, Candace, Louie, Allen, Zhou, Yi, Gupta, Rajat, Liang, Fengting, Xanthou, Georgina, Ereso, Jason, Koletic, Carolina, Yang, Julianne Ching, Sedighian, Farzaneh, Lagishetty, Venu, Arias-Jayo, Nerea, Altuwayjiri, Abdulmalik, Tohidi, Ramin, Navab, Mohamad, Reddy, Srinivasa Tadiparthi, Sioutas, Constantinos, Hsiai, Tzung, Araujo, Jesus A., Jacobs, Jonathan P.
المصدر: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7184, 16p
مصطلحات موضوعية: DEXTRAN sulfate, SODIUM sulfate, PARTICULATE matter, EPITHELIAL cells, COLITIS, INFLAMMATORY bowel diseases, TRICHLOROPHENOL
مستخلص: Inflammatory bowel disease (IBD) is an immunologically complex disorder involving genetic, microbial, and environmental risk factors. Its global burden has continued to rise since industrialization, with epidemiological studies suggesting that ambient particulate matter (PM) in air pollution could be a contributing factor. Prior animal studies have shown that oral PM10 exposure promotes intestinal inflammation in a genetic IBD model and that PM2.5 inhalation exposure can increase intestinal levels of pro-inflammatory cytokines. PM10 and PM2.5 include ultrafine particles (UFP), which have an aerodynamic diameter of <0.10 μm and biophysical and biochemical properties that promote toxicity. UFP inhalation, however, has not been previously studied in the context of murine models of IBD. Here, we demonstrated that ambient PM is toxic to cultured Caco-2 intestinal epithelial cells and examined whether UFP inhalation affected acute colitis induced by dextran sodium sulfate and 2,4,6-trinitrobenzenesulfonic acid. C57BL/6J mice were exposed to filtered air (FA) or various types of ambient PM reaerosolized in the ultrafine size range at ~300 μg/m3, 6 h/day, 3–5 days/week, starting 7–10 days before disease induction. No differences in weight change, clinical disease activity, or histology were observed between the PM and FA-exposed groups. In conclusion, UFP inhalation exposure did not exacerbate intestinal inflammation in acute, chemically-induced colitis models. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Complementary Index
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