دورية أكاديمية
The dynamic strategy shifting task: Optimisation of an operant task for assessing cognitive flexibility in rats.
| العنوان: | The dynamic strategy shifting task: Optimisation of an operant task for assessing cognitive flexibility in rats. |
|---|---|
| المؤلفون: | Flintoff, Jonathan Martin, Alexander, Suzy, Kesby, James Paul, Burne, Thomas Henry |
| المصدر: | Frontiers in Psychiatry; 2024, p1-16, 16p |
| مصطلحات موضوعية: | COGNITIVE flexibility, DELUSIONS, SPRAGUE Dawley rats, VISUAL discrimination, EXECUTIVE function, RATS |
| مستخلص: | Introduction: Although schizophrenia is associated with a broad range of symptoms including hallucinations, delusions, and reduced motivation, measures of cognitive dysfunction, including cognitive flexibility and executive function, are the strongest predictors of functional outcomes. Antipsychotic medications are useful for reducing psychotic symptoms, but they are ineffective at improving cognitive deficits. Despite extensive investment by industry, the transition from preclinical to clinical trials has not been successful for developing precognitive medications for individuals with schizophrenia. Here, we describe the optimisation of a novel dynamic strategy shifting task (DSST) using standard operant chambers to investigate the optimal stimuli required to limit the extensive training times required in previous tasks. Methods: We determined that optimal learning by male and female Sprague Dawley rats for the flexibility task incorporated dynamic strategy shifts between spatial rules, such as following a visual cue or responding at one location, and non-spatial rules, such as responding to a central visual or auditory cue. A minimum of 6 correct consecutive responses were required to make a withinsession change in the behavioural strategies. As a proof of concept, we trained and tested 84 Sprague Dawley rats on the DSST, and then assessed their cognitive flexibility using a within-subject design after an acute dose of ketamine (0, 3, 10 mg/kg). Rats made fewer premature and more perseverant responses to initiate a trial following ketamine. The effects of ketamine on trials to criterion was dependent on the rule. Results: Ketamine induced a significant improvement on the reversal of a nonspatial visual discrimination rule. There was no significant effect of ketamine on the spatial visual or response discrimination rules. Discussion: The DSST is a novel assay for studying distinct forms of cognitive flexibility and offers a rapid and adaptable means of assessing the ability to shift between increasingly challenging rule conditions. The DSST has potential utility in advancing our understanding of cognitive processes and the underlying neurobiological mechanisms related to flexibility in neuropsychiatric and neurological conditions where executive dysfunctions occur. [ABSTRACT FROM AUTHOR] |
| Copyright of Frontiers in Psychiatry is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder كن أول من يترك تعليقا!