دورية أكاديمية
EXPLORING PHYTOCHEMICAL DIVERSITY AND BIOLOGICAL ACTIVITIES OF HYPERICUM JAPONICUM AND HYPERICUM SAMPSONII: POTENTIAL FOR NATURAL PRODUCT-BASED APPLICATIONS.
| العنوان: | EXPLORING PHYTOCHEMICAL DIVERSITY AND BIOLOGICAL ACTIVITIES OF HYPERICUM JAPONICUM AND HYPERICUM SAMPSONII: POTENTIAL FOR NATURAL PRODUCT-BASED APPLICATIONS. |
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| المؤلفون: | Paula, Barciela, Ana, Perez-Vazquez, Daniele, Bobrowski Rodrigues, da Silveira Tayse, Ferreira Ferreira, Tânia, Pires Cristina, Filipa, Mandim, Maria, Carpena, Lilian, Barros, Miguel, Prieto Angel |
| المصدر: | Genetics & Applications; 2024 Special Issue, p80-81, 2p |
| مستخلص: | This study represents the first comprehensive investigation into the phenolic profiles and biological properties of whole Hypericum japonicum and Hypericum sampsonii, two medicinal plant species within the genus Hypericum, revealing distinct chemical and bioactive properties of their extracts. Phenolic compounds, plant secondary metabolites widely recognized as bioactive, were extracted from the dried whole plant of each species and analysed by HPLC-DAD-MS/MS, and the bioactivities were assessed using in vitro methods. The predominant phenolic families differed between the two species, with flavonoids such as taxifolin-O-rhamnoside, isoquercitrin, and quercitrin being the major compounds found in H. japonicum. A total of 30 phenolic compounds were identified in this specie with a significantly higher total phenolic content (TPC = 184.51±0.2 mg/g extract dw) than H. sampsonii (TPC = 59.57±0.8 mg/g extract dw). In the latter species, 17 compounds were identified and quantified, being xanthones such as mangiferin, besides rutin, and hyperoside among the most prevalent compounds in H. sampsonii extract. Additionally, four different classes of previously unidentified anthocyanins were discovered in H. sampsonii, collectively amounting to 303.94±0.3 mg/g of extracted dw. The antioxidant activity assessed using the OxHLIA and TBARS methods yielded values of EC50 that were either equal to or superior to the positive control tested (Trolox). Additionally, the extracts exhibited promising antitumor effects, with particular significance attributed to the remarkable GI50 value of H. japonicum against the human gastric adenocarcinoma (AGS) cell line (69±2 μg/mL extract). While further research is warranted to generalize the cytotoxic activity, both extracts showed remarkable antimicrobial efficacy, with H. japonicum extract exhibiting minimum inhibitory concentration (MIC) values as low as 0.007 mg/mL against various clinical and food bacterial strains. Overall, the assessment of biological properties suggests that H. japonicum exhibits greater potential compared to H. sampsonii, likely due to its threefold higher TPC content. These findings suggest promising avenues for future research, including isolating key compounds and exploring these extracts as versatile functional foods and potent antioxidants across different sectors. Moreover, the possibility of developing pharmacological products based solely on concentrated herbal preparations or standardized extracts of Hypericum opens new horizons in natural product-based therapeutics.8,9- dehydrothymol methyl ether, 8,9-dehydrothymol and 8,9-dehydro-4-hydroxythymol dimethyl ether. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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