دورية أكاديمية
Kv1.3-induced hyperpolarization is required for efficient Kaposi's sarcoma–associated herpesvirus lytic replication.
العنوان: | K |
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المؤلفون: | Carden, Holli, Harper, Katherine L., Mottram, Timothy J., Manners, Oliver, Allott, Katie L., Dallas, Mark L., Hughes, David J., Lippiat, Jonathan D., Mankouri, Jamel, Whitehouse, Adrian |
المصدر: | Science Signaling; 7/16/2024, Vol. 17 Issue 845, p1-11, 11p |
مصطلحات موضوعية: | KAPOSI'S sarcoma-associated herpesvirus, POTASSIUM channels, B cells, T cells, KAPOSI'S sarcoma, GENE silencing, LATENT infection, GENETIC transcription |
مستخلص: | Kaposi's sarcoma–associated herpesvirus (KSHV) is an oncogenic herpesvirus that is linked directly to the development of Kaposi's sarcoma. KSHV establishes a latent infection in B cells, which can be reactivated to initiate lytic replication, producing infectious virions. Using pharmacological and genetic silencing approaches, we showed that the voltage-gated K+ channel K |
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قاعدة البيانات: | Complementary Index |
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