دورية أكاديمية
Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein.
| العنوان: | Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ET |
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| المؤلفون: | Owen, Nicola E., Williams, Thomas L., Maguire, Janet J., Kuc, Rhoda E., Davenport, Emma E., Davenport, Anthony P. |
| المصدر: | Bioscience Reports; Jul2024, Vol. 44 Issue 7, p1-19, 19p |
| مصطلحات موضوعية: | ENDOTHELIN receptors, LIVER regeneration, THROMBIN receptors, PORTAL vein, PREPROENDOTHELIN, DOWNREGULATION, TRANSCRIPTION factors, LIFE sciences |
| مستخلص: | This article discusses a study that analyzed gene expression in portal veins from patients with portal hypertension (PH) and cirrhosis. The study identified several genes that could be potential drug targets for the treatment of PH. The findings suggest that targeting genes involved in the endothelin pathway and G protein-coupled receptors could be beneficial in treating PH. The article also mentions the potential use of ETA receptor antagonists as a therapy for PH. Additionally, the document provides a list of references for further research on liver transplantation, portal hypertension, and the use of different medications in the treatment of cirrhosis. [Extracted from the article] |
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| قاعدة البيانات: | Complementary Index |
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