التفاصيل البيبلوغرافية
| العنوان: |
A new cyclodipeptide from Tetragonisca angustula honey active against Neospora caninum and in silico study. |
| المؤلفون: |
de Oliveira Lima, Ângela Cristina, Nolasco, Matheus, Freitas, Luciana dos Santos, Pinheiro, Alexandre Moraes, de Carvalho, Carlos Alfredo Lopes, de Freitas, Humberto Fonseca, Pita, Samuel Silva da Rocha, Vieira, Ivo José Curcino, Braz Filho, Raimundo, Branco, Alexsandro |
| المصدر: |
Natural Product Research; Aug2024, Vol. 38 Issue 16, p2909-2914, 6p |
| مصطلحات موضوعية: |
NEOSPORA caninum, HONEY, SUCCINIC acid, DNA synthesis, CYCLIC compounds, OLIGOPEPTIDES |
| مستخلص: |
A new cyclic natural compound formed by succinic acid and two alanine amino acid units was isolated from the Tetragonisca angustula honey extract. The chemical structure of 1 was established based on spectroscopic data analysis, including one- (1H and 13C NMR) and two-dimensional NMR techniques (1H-1H-COSY, HSQC and HMBC). A primary culture model previously infected with Neospora caninum was used to evaluate 1 for two time intervals (24 and 72 h), showing a reduction (40-56%) of the number of tachyzoites in the first 24 h and until 72 h, a dose-dependent reduction in parasite proliferation (25-50%). Glial cells treated with 1 did not demonstrate toxicity at concentrations up to 25 ug/mL. Treated and infected cultures showed an increase in NO when compared to control cells in 24 h and 72 h. In silico studies suggest that the new compound may affect DNA synthesis and impair -protein production. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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